Clinical Pathology and Treatment of Renin-Angiotensin System 2. Chronic Kidney Disease and the Renin-Angiotensin System
نویسندگان
چکیده
منابع مشابه
Renin-angiotensin system and unilateral ureteral obstruction
Unilateral ureteral obstruction (UUO) is a clinical scenario that leads to obstructive nephropathy. UUO alters the expression of many mediators in the ipsilateral kidney. Renin-angiotensin system (RAS) is involved in UUO. Angiotensin II (Ang II) and angiotensin 1-7 (Ang 1-7) as the main arms of RAS influence kidney function which may alter by UUO. Ang II via Ang II receptor subtypes I (AT1R) ...
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Atherosclerosis is an inflammatory disease characterized by endothelial dysfunction, thereby leading to the accumulation of macrophage-derived foam cells in the vessel wall. Endothelial cells, intimal smooth muscle cells, and leukocytes produce a wide range of inflammatory cytokines, chemokines, and growth factors in the multifactorial process of atherosclerosis. Angiotensin II (Ang II) has bee...
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متن کاملRenin-Angiotensin-Aldosterone System Antagonism and Polycystic Kidney Disease Progression.
Autosomal Dominant Polycystic Kidney Disease (ADPKD) is a systemic disease characterised by the formation of multiple renal cysts that adversely affect renal function. ADPKD shows significant progression with age when complications due to hypertension are most significant. The activation of the renin-angiotensin-aldosterone system (RAAS) occurs in progressive kidney disease leading to hypertens...
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Inhibition of the renin-angiotensin-aldosterone system (RAAS) plays a pivotal role in treatment of chronic kidney diseases (CKD). However, reversal of the course of CKD or at least long-term stabilization of renal function are often difficult to achieve, and many patients still progress to end-stage renal disease. New treatments are needed to enhance protective actions of RAAS inhibitors (RAASi...
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ژورنال
عنوان ژورنال: Internal Medicine
سال: 2007
ISSN: 0918-2918,1349-7235
DOI: 10.2169/internalmedicine.46.1908